What is granulation?

One of the first steps in the tablet manufacturing process is blending the active pharmaceutical ingredient (API) and the excipients (these are components other than the active substances) until a homogeneous mixture is achieved. Granulation helps with this, and it is done either in a free fall blender or in a high-shear mixer with strong shear forces if the API is low-dose.

Granulation is commonly used in three cases:

  1. When simple blending does not produce suitable physicochemical properties, e.g. when the blend has low density or poor flow properties.
  2. If the formulation needs special attributes that cannot be achieved with simple blending e.g. gastroresistance, sustained release and taste-masking
  3. To add excipients that cannot be mixed in their dry form.
    And there are three types of granulation in the pharmaceutical industry: dry granulation (also known as compaction), wet granulation and melt granulation.

Acino’s facilities are equipped with state-of-the art equipment to manufacture tablets, granules and more. Reach out to us to learn how we can support your tableting or granulation projects.